Information on Crohn's disease from the National Institute of Diabetes and Kidney Disorders
Crohn's disease is an ongoing disorder that causes inflammation of the digestive tract, also referred to as the gastrointestinal (GI) tract. Crohn's disease can affect any area of the GI tract, from the mouth to the anus, but it most commonly affects the lower part of the small intestine, called the ileum. The swelling extends deep into the lining of the affected organ. The swelling can cause pain and can make the intestines empty frequently, resulting in diarrhea... more from National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health.
Crohn's Disease Information from the Mayo Clinic
Information on Crohn's disease from MayoClinic.com.
Information on Crohn's Disease from Johns Hopkins
Inflammatory bowel disease encompasses two idiopathic, chronic, inflammatory diseases: Crohn’s disease and ulcerative colitis. Crohn’s disease and ulcerative colitis are disorders of unknown cause, involving genetic and immunological influence on the gastrointestinal tract’s ability to distinguish foreign from self-antigens. They share many overlapping epidemiological, clinical, and therapeutic characteristics. In some patients it is not possible to distinguish which form of inflammatory bowel disease is present...more at Johns Hopkins Medicine Gastroenterology & Hepatology.
Quiz: Crohn's Disease or Ulcerative Colitis?
Crohn's disease and ulcerative colitis are the two common types of Inflammatory Bowel Disease. They are similar in symptoms, presentation and treatment but have some distinctive characteristics. Test your IBD IQ and see if you can tell the difference between the two. Take the quiz at Health Central.
Patient Voices: Crohn’s Disease
How does Crohn’s disease affect the lives of the young? How do men and women cope with the embarrassing symptoms and sometimes invasive treatments? Listen to the stories of seven men and women living with Crohn's disease. Listen at the New York Times Health Guide.
Scientists find new major susceptibility genes for Crohn's disease.
Just a few months after their landmark article in Science magazine reporting the discovery of strong links between variations in a gene that codes for a cellular receptor involved in controlling inflammation and Crohn's disease, a consortium of U.S. and Canadian researchers is reporting in today’s online issue of Nature Genetics that they have discovered several more genetic variations that are strongly linked to an increased risk for the disease. See the UPMC press release.
Video: Crohn's disease basics
Learn the basics of Crohn's disease, including signs and symptoms, diagnosis information and risk factors. You’ll also find out how Crohn's can affect you over the long term…View the video at Crohn's Online.
Video: Crohn's Disease - A Real Story
Crohn's disease is an inflammatory disease of the gut. Joseph Barr describes his experience of the condition, including the tests, symptoms and treatment..View the video at the UK's National Health Service website.
Video: An Expert Discusses Crohn's
An expert discusses the symptoms and treatment options for Crohn's disease, an inflammation of the gut at the UK's National Health Service website.
Podcast: Enjoying Eating
Listen in to learn how people with Crohn’s disease can maintain a healthy diet from registered dietitian Tracie Dalessandro presented by Crohn's Online.
Podcast: Crohn’s Disease and Ulcerative Colitis
Dr. Kerry Hammond, assistant professor of surgery at the Digestive Disease Center at MUSC, discusses Irritable Bowel Disease, the most common forms of which are Crohn’s Disease and Ulcerative Colitis…Listen at the MUSC Podcast Library.
Practice parameters for the surgical management of Crohn's disease.
Patients with disease-related symptoms who suffer from medically unresponsive disease, demonstrate an inadequate response, manifest medication-related complications, or appear noncompliant with medication should be considered for operation. See National Guideline Clearinghouse major recommendations.
Imaging Recommendations for Crohn's disease.
Crohn's disease (CD) is a chronic inflammatory disease involving the gastrointestinal tract. The etiology is unknown, but evidence suggests that a genetic predisposition combined with an abnormal interaction between the gut and enteric microorganisms may play a role in the pathogenesis. See National Guideline Clearinghouse major recommendations.
Endoscopy in the diagnosis and treatment of inflammatory bowel disease.
The value of endoscopy alone in distinguishing IBD from non-IBD colitides is limited. However, the acquisition of the detailed information from index colonoscopy is important for the differential diagnosis of Crohn's disease (CD) and ulcerative colitis (UC) because, once therapy is started, it may obscure discriminating features of CD from UC such as segmental colitis (patchiness) and rectal sparing. See National Guideline Clearinghouse major recommendations.
Abstract: Bacteria in Crohn's disease: mechanisms of inflammation and therapeutic implications.
Microbial agents are implicated in each of the most prevalent etiologic hypotheses of Crohn's disease. Although chronic infection with a specific, persistent pathogen cannot be excluded, it is more likely that Crohn's disease is caused by an overly aggressive immune response to normal commensal enteric bacteria. See Abstract at PubMed.
Abstract: Coping strategy when patients with quiescent Crohn's disease recognize that their conditions are worsening.
Although self-management is important for Crohn's disease (CD), there is no research focusing on self-management, especially in worsening conditions. The purpose of this study was to investigate how quiescent CD patients cope with their conditions worsening. See Abstract at PubMed.
Abstract: Importance of nutrition in inflammatory bowel disease.
IBD is associated with frequent nutritional deficiencies, the pattern and severity of which depends on the extent, duration and activity of the inflammation. Nutritional support allows these deficiencies in calories, macro- and micro-nutrients to be rectified. Enteral nutrition is also a primary therapy for IBD, especially for Crohn's disease, as it allows the inflammatory activity to be controlled, kept in remission, and prevents or delays the need for surgery. See Abstract at PubMed.
Abstract: Enteroscopy in the diagnosis and management of Crohn's disease.
Evaluation of patients with suspected Crohn's disease has traditionally involved the use of ileocolonoscopy, push enteroscopy, and barium small bowel radiography. A large proportion of patients with mild small bowel disease or involvement of the mid small bowel can potentially be missed if only these tests are utilized. Enteroscopy is defined as direct visualization of the small bowel using a fiber optic or wireless endoscope. See Abstract at PubMed.
Abstract; Enteral nutritional therapy for induction of remission in Crohn's disease.
The role of enteral nutrition in Crohn's disease is controversial. Increasing research on the mechanisms by which nutritional therapy improves the clinical well being of patients with Crohn's disease has led to novel formula design and trials comparing two different forms of enteral nutrition. See Abstract at PubMed.
Abstract: Budesonide for maintenance of remission in Crohn's disease.
Corticosteroids have been shown to be effective for induction, but not maintenance of remission in Crohn's disease. However, significant concerns exist regarding their risk for adverse events, particularly when used for long treatment courses. Budesonide is a glucocorticoid with limited systemic bioavailability due to extensive first-pass hepatic metabolism. Budesonide has been shown to be effective for induction of remission in Crohn's disease. See Abstract at PubMed.
Abstract: Traditional corticosteroids for induction of remission in Crohn's disease.
Historically, corticosteroids have been the most commonly used class of medication for induction of remission in Crohn's disease (CD). Corticosteroids down regulate production of inflammatory cytokines and interfere with NF-kappaB production, thereby blunting inflammatory response. See Abstract at PubMed.
Abstract: Cyclosporine for induction of remission in Crohn's disease.
Cyclosporine was first found to be an effective and well-tolerated immunosuppressive agent in organ transplant recipients, and subsequently in several autoimmune diseases. It was reported in open studies that cyclosporine is effective for induction of remission in Crohn's disease. See Abstract at PubMed.
Abstract: Efficacy of methotrexate in Crohn's disease and ulcerative colitis patients unresponsive or intolerant to azathioprine/mercaptopurine.
Despite the wide use of azathioprine/mercaptopurine (AZA/MP) therapy in the management of both Crohn's disease (CD) and ulcerative colitis (UC), approximately 20% of patients cannot tolerate the drugs and 30% do not respond. Aim To examine the efficacy and safety profile of MTX in patients with CD or UC who are either intolerant or non-responsive to AZA/MP. See Abstract at PubMed.
Abstract; Natalizumab for induction of remission in Crohn's disease.
The pathogenesis of Crohn's disease involves migration of leukocytes into gut tissue and subsequent inflammation. Natalizumab (Tysabri, Elan Pharmaceuticals and Biogen Idec) a recombinant humanized IgG4 monoclonal antibody that blocks adhesion and subsequent migration of leukocytes into the gut by binding the alpha4 integrin is a member of a new class of molecules known as selective adhesion molecule (SAM) inhibitors. The results of animal studies suggest that alpha4 integrin blockade could be a useful therapy for inflammatory bowel disease. See Abstract at PubMed.
Abstract: DNA-driven nutritional therapy of inflammatory bowel disease.
Crohn's disease shows strong association with CARD15, ATG15L1, and IRGM, which are involved in the innate immunity. In the adaptive immune response, IL23R, MST1, IL12B, and STAT3 polymorphisms are associated with Crohn's disease and ulcerative colitis. Current pharmacologic treatment of IBD, including 5-aminosalycylate, steroids, and immunomodulator therapy, are mainly aimed at suppressing inflammation non-specifically, except biologic therapies such as anti-tumor necrosis factor molecule, which block specific proinflammatory molecules. See Abstract at PubMed.
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Distribution of Crohn's Disease in the intestinal tract
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