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Lupus — Overview, Symptoms, Treatments, and Other Resources.
Lupus (also known as Systemic Lupus Erythematosis or SLE)
Comprehensive Guides
Information on Lupus from the National Library of Medicine
Lupus is a disease in which the immune system attacks tissues of the body and damages them. The cause is unknown, but believed to be influenced by a combination of genetic and environmental factors. Symptoms vary for each individual with lupus, but common symptoms include: painful or swollen joints, rash on the face (so-called butterfly rash, due to its shape), sensitivity to sun, unexplained fever, muscle pain, and extreme fatigue. Lupus is diagnosed using a combination of diagnostic laboratory testing and physical examination. With adequate management, individuals with Lupus can live active lives. Treatments typically aim to reduce inflammation and suppress the immune system. View a detailed overview of lupus at the National Library of Medicine.

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Information on Lupus from the Lupus Foundation of America
If you or a family member has been diagnosed with or are being evaluated for possible lupus, you will want to know as much as you can about the disease. "Understanding Lupus" will provide you with a guide to lupus so that you can better understand what lupus is. Read more at the Lupus Foundation of America.

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Information on Lupus from the Mayo Clinic
Lupus…Read more at MayoClinic.com.

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Fact Sheets, Tutorials, Interactive Tools, and other Interesting Information
Fact Sheet: The NIH on Lupus
Lupus (systemic lupus Erythematosis) is a serious and potentially fatal autoimmune disease that mainly affects young women. The disease often starts between the ages of 15 and 44. The manifestations of lupus are diverse…Read more at the National Institutes of Health.

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An interactive tutorial - systemic lupus Erythematosis
The immune system of individuals with lupus attacks healthy tissues. The disease can affect every organ in the body. The symptoms and their severity vary greatly from person to person. Treatment allows many individuals to continue enjoying most of the activities they did before they were diagnosed. View the interactive tutorial at the National Library of Medicine.

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Tutorial - The Impact of Lupus on the body
Use the Lupus Foundation of America's interactive tool.

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Videos and Podcasts
Podcast Podcast: Patient voices on lupus
Here, six people affected by lupus speak about their experiences. Listen at the New York Times Healthguide.

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Podcast Podcast: Lupus and kidney disease
The immune system of individuals with lupus may produce large quantities of antibody, which can lead to kidney damage. Since lupus is a chronic disease, patients may require kidney function monitoring for the remainder of their lives. Listen to the podcast from the Renal Support Network.

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Podcast Podcast: Unlocking the secrets of autoimmune diseases
23 million Americans live with some form of autoimmune disease. One million of these individuals have lupus. Medical research is beginning to unlock the cause of lupus and how it progresses. What we learn about lupus will likely lead to a better understanding of all autoimmune diseases. Listen to the podcast from the Lupus Foundation of America.

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Clinical Practice Guidelines
Importance of managing systemic lupus erythematosus during pregnancy
Women planning to become pregnant should take care to control their lupus symptoms, as the disease may impair fertility or increase the risk of pregnancy for both mother and child. Approximately 30% of pregnant women with lupus experience exacerbation of their symptoms. Pregnancy is especially dangerous if the mother has circulating antibodies to phospholipids. View the National Guideline Clearinghouse major recommendations.

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Children with lupus should undergo cardiac assessment prior to participating in athletics
A potential side effect of lupus is inflammation in or around the heart. In general, children with lupus may participate in sports activities. However, they should first be assessed by their physician to determine that the disease has not affected their cardiovascular system in a way that would pose a danger to the child. View the National Guideline Clearinghouse major recommendations.

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Oral contraceptive use is safe in women with SLE.
Women with mild lupus may take oral contraceptives provided that they do not have circulating phospholipid antibodies. The presence of phospholipid antibodies increases the risk of cardiac damage from the disease. View the National Guideline Clearinghouse major recommendations.

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Important Articles from Medical Journals
Abstract: Lupus is caused by numerous immune system abnormalities.
Lupus is an autoimmune disease in which the body attacks healthy body tissue. The cause of lupus is complex, but many years of medical research are helping scientists understand which parts of the immune system function incorrectly in Lupus patients. View the abstract in Pubmed.

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Abstract: Identifying biomarkers of kidney inflammation in lupus patients
Kidney inflammation, or nephritis, is a serious potential complication of lupus. Typically, individuals are treated by suppressing the immune system. However, the inflammation comes and goes, so treatment regimens should be adjusted accordingly. Scientists are looking for biomarkers that will predict when nephritis is likely to occur, so therapy can be adjusted as necessary. View the abstract at Pubmed.

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Abstract: A potential new class of Lupus drugs targets a key component of the immune system
Lupus is an autoimmune disease characterized by the presence of antibodies to DNA and RNA. I normal individuals, the immune system ignores these molecules. Numerous recent studies have identified a family of proteins, TLRs, that exacerbate the production of self-antibodies. Synthetic inhibitors of TLRs improve lupus symptoms in mice. View the abstract at Pubmed.

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Abstract: A potential new class of lupus drugs may have less side effects.
Lupus is a chronic autoimmune disorder, often leading to damage in multiple organs. The most common medications used to treat lupus, though effective for symptom control, may have side effects throughout the body. Ideally, treatments should aim to block the abnormal immune system components, while sparing the remainder of the body. One potential class of these drugs is antibodies. View the abstract at Pubmed.

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Abstract: Individuals with lupus have genetic variations that raise their risk of developing the autoimmune disorder.
Individuals possessing certain genes are more likely to develop the autoimmune disorder systemic lupus erythematosus (SLE). 17 genes that may put an individual at high risk of developing SLE have been identified. Together, these genes regulate several components of the immune system known to contribute to the disease. View the abstract in Pubmed.

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Abstract: Identifying the targets of the immune system in Lupus patients may shed light on how the disease begins and progresses.
Autoimmune diseases that affect the entire body share many features. However, the molecular targets of each disease are distinct. The identification of these targets for each individual autoimmune disease may improve our understanding of how these complex diseases start and progress. View the abstract at Pubmed.

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Abstract: A new class of experimental Lupus drugs work as decoys to mimic the healthy tissue that the immune system attacks
Lupus is an autoimmune disorder, in which a person’s immune system attacks small pieces of their own cells. This hyperactivity of the immune system requires the interaction of two cell types, B cells and T cells, which both recognize the self-molecule. Preclinical trials in animals have shown promise for a class of molecules that specifically block the interaction of B and T cells. View the abstract in Pubmed.

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Looking for a Top-Rated Immunologist, Rheumatologist, or Nephrologist?
Consumers' Guide to Top Doctors finds the Doctors Rated Best by other Doctors
To find out who the top doctors are around the country, nonprofit Consumers' CHECKBOOK surveyed roughly 340,000 physicians to tell us which specialists they would want to care for a loved one. The Top Doctors database contains the names of over 23,000 doctors who were mentioned most often. Find top-rated doctors in the fifty largest metropolitan areas, in over thirty-five specialties, and more.
Symptoms of Lupus
Source: Wikimedia

Consumers' Guide to Top Doctors finds the Doctors Rated Best by other Doctors in over 30 specialties.

Search Top Doctors database of 23,000 top-rated physicians by Doctor's Name

Search Top Doctors database of 23,000 top-rated physicians by Specialty (over 35 different fields included)

Source: cure4lupus.org

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