Ovarian Cancer at the National Institutes of Health (NIH)
The sooner ovarian cancer is found and treated, the better your chance for recovery. But ovarian cancer is hard to detect early. Many times, women with ovarian cancer have no symptoms or just mild symptoms until the disease is in an advanced stage and hard to treat. Read more at Medline Plus, a service of the US National Library of Medicine and the National Institutes of Health.
Ovarian Cancer at MD Anderson Cancer Center
Currently, there is no effective early detection method for ovarian cancer. It is usually diagnosed in advanced stages, and only about half of women survive longer than five years after diagnosis. For the 25% of ovarian cancers that are found early, the five-year survival rate is greater than 90%. More information available from the MD Anderson Cancer Center.
Ovarian Cancer at Memorial Sloan-Kettering Cancer Center
Ovarian cancer is the second most common type of gynecologic cancer. Of the different types of ovarian cancer, epithelial ovarian cancer is the most common, originating in the cells that cover the surface of the ovary, which are known as epithelial cells. Other rarer kinds of ovarian cancer include germ cell and stromal cell tumors. More information available from the Memorial Sloan-Kettering Cancer Center.
Ovarian cancer: Essentials from Consumer Reports
What is it? What are the symptoms? How is it diagnosed? How common is it? What will happen? Questions to ask.
Key points about treatments from Consumer Reports.
Ovarian Cancer Risk - Interactive Questionnaire
"Your Ovarian Cancer Disease Risk" questionnaire provided by the Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine.
Fact Sheet: Ovarian Cancer
This fact sheet about ovarian cancer is part of the Centers for Disease Control and Prevention’s (CDC) National Gynecologic Cancer Awareness Campaign. The campaign helps women get the facts about gynecologic cancer, providing important ‘inside knowledge’ about their bodies and health.
Animated Interactive Tool: Understanding Ovarian Cancer
View an animated and narrated presentation on ovarian cancer at Discovery Health.
Pamphlet: What you need to know about ovarian cancer
This National Cancer Institute (NCI) booklet is about ovarian epithelial cancer. It is the most common type of ovarian cancer. It begins in the tissue that covers the ovaries. You will read about possible causes, symptoms, diagnosis, and treatment. You will also find lists of questions to ask your doctor. It may help to take this booklet with you to your next appointment.
Video: Ovarian Cancer Awareness
Ovarian cancer effects everyone, men and women, mothers, fathers, sisters, brothers and friends. View multiple PSA videos at OvarianCancerAwareness.org.
Podcast: Ovarian Cancer Awareness
Dr. Judith Wolf and survivor/volunteer Andrea Quinn talk about diagnosis, treatment and the work being done to raise money for ovarian cancer research. Listen to this MD Anderson Cancer Center podcast.
Podcast: Ovarian Cancer Treatment Advances
New advances in drug development and surgical techniques for ovarian cancer will be discussed. Watch this webcast, presented by the MD Anderson Cancer Center.
Podcast: Ovarian Cancer: Warning Signs
Ovarian Cancer is a rare but serious form of cancer. Early detection is difficult but a new list of warning signs released in June of 2007 is a reminder to women to be aware of their risk. Siteman Cancer Center gynecologic oncologist, David Mutch, MD, discusses the challenges to recognizing this rare form of cancer. Listen to this podcast, presented by the Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine.
Video: Ovarian Cancer Symptoms Awareness
Know Your Body. Know the Symptoms. Help Spread the Word. View multiple PSA videos, presented by The Ovarian Cancer National Alliance.
Ovarian Cancer Screening: Recommendation Statement
There is no existing evidence that any screening test, including CA-125, ultrasound, or pelvic examination, reduces mortality from ovarian cancer. Furthermore, existing evidence that screening can detect early-stage ovarian cancer is insufficient to indicate that this earlier diagnosis will reduce mortality. See National Guideline Clearinghouse major recommendations.
Recurrent Ovarian Cancer Treatment: Chemotherapy Recommendation Statement
Use of systemic therapy in women with recurrent ovarian cancer – development, methods and clinical practice guideline. See National Guideline Clearinghouse major recommendations.
First-Line Ovarian Cancer Treatment: Chemotherapy Recommendation Statement
First-line chemotherapy for postoperative patients with stage II, III or IV epithelial ovarian cancer, fallopian tube cancer, or primary peritoneal cancer. See National Guideline Clearinghouse major recommendations.
Ovarian Cancer Clinical Article: Current management strategies for ovarian cancer.
We provide an overview of ovarian cancer with particular emphasis on recent advances in operative management and systemic therapies. Full text available free through Pubmed.
Ovarian Cancer Clinical Article: Recurrent ovarian cancer: how important is it to treat to disease progression?
A number of active agents in ovarian cancer (platinum, paclitaxel, topotecan, liposomal doxorubicin, docetaxel, gemcitabine, and etoposide) will be reviewed in the context of what is known about cumulative toxicity, potential adverse effects on patients' quality of life, and evidence addressing the potential benefits of longer-term treatment. Full text available free through Pubmed.
Ovarian Cancer Research Abstract: Breast and Ovarian Cancer Risks Due To Inherited Mutations in BRCA1 and BRCA2.
Risks of breast and ovarian cancer were determined for Ashkenazi Jewish women with inherited mutations in the tumor suppressor genes BRCA1 and BRCA2. Abstract available through PubMed. Full text available free (with registration) through Science.
Ovarian Cancer Research Article: Prediction of ovarian cancer prognosis and response to chemotherapy by a serum-based multiparametric biomarker panel.
Currently, there are no effective biomarkers for ovarian cancer prognosis or prediction of therapeutic response. The objective of this study was to examine a panel of 10 serum biochemical parameters for their ability to predict response to chemotherapy, progression and survival of ovarian cancer patients. Full text available free through the British Journal of Cancer.
Ovarian Cancer Research Abstract: BubR1 as a prognostic marker for recurrence-free survival rates in epithelial ovarian cancers.
Epithelial ovarian cancer is one of the most lethal malignancies, and has a high recurrence rate. Thus, prognostic markers for recurrence are crucial for the care of ovarian cancer. As ovarian cancers frequently exhibit chromosome instability, we aimed at assessing the prognostic significance of two key mitotic kinases, BubR1 and Aurora A. Abstract available through PubMed.
Ovarian Cancer Research Abstract: Ovarian cancer and oral contraceptives: collaborative reanalysis of data from 45 epidemiological studies including 23,257 women with ovarian cancer and 87,303 controls.
Use of oral contraceptives confers long-term protection against ovarian cancer. These findings suggest that oral contraceptives have already prevented some 200,000 ovarian cancers and 100,000 deaths from the disease, and that over the next few decades the number of cancers prevented will rise to at least 30,000 per year. Abstract available through PubMed.
Ovarian Cancer Research Article: Challenges for chemotherapy in ovarian cancer.
Ovarian cancer is treated with surgery followed by combination chemotherapy with paclitaxel plus carboplatin. In an effort to improve outcomes, clinical trials are evaluating the following strategies: maintenance therapy; intraperitoneal drug administration; new combinations; novel cytotoxics; combination chemotherapy for recurrent disease; and molecular-targeted therapies. Full text available free through Pubmed.
Ovarian Cancer Research Article: Clinical testing of engineered oncolytic measles virus strains in the treatment of cancer: an overview.
Strains of the attenuated measles virus Edmonston (MV-Edm) vaccine lineage can preferentially infect and destroy cancerous cells while sparing the surrounding tissues. Preclinical efficacy and safety data for engineered oncolytic MV-Edm derivatives that led to their clinical translation are discussed in this review, and an overview of the early experience in three ongoing clinical trials of patients with ovarian cancer, glioblastoma multiforme and multiple myeloma is provided. Full text available free through Pubmed.
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